102331. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. <> Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). PharmaCentral 2021 . : 5. Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? Catalog Number 102331. However, it yields non-digestible fibre. They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. High performance lubricant that brings more to the tablet. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. Truly distinctive drug delivery solutions. 2008-2023 ChemPoint. 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream The cellulose molecule is formed through repeated condensation of cellobiose units. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . Cellulose microcrystalline. iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. Micro Crystalline Cellulose. Buy Chemicals. Eur., JPE . Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. 51395-75-6 Avicel RC 591. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . ( Aqueous suspensions of microcrystalline cellulose have . >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) endobj J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? AVICEL RC 581. : 160182 Date Approved: 05/25/2010 Revision No. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. All Rights Reserved. Avicel PC 611 (FMC Biopolymer) Supplied by. More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. /Resources 2 0 R Document(s): certificate data msds. Explore how you can develop your career and bring your creative ideas to life at IFF. Synonyms: Cellulose, Cellulose powder, Cotton linters. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. Material safety data sheet - FMC Corporation. The most. : 51395-75-6 Date Approved: 01/31/2008 Revision No. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. Gloves, eye protection and a dust mask should be used. Wu, K. Zuurman, H.W. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. There may be more fiber in your food than you realized. Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. lH5JWy}DgKRR"Fs Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, l~5C It . Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. Performing this action will revert the following features to their default settings: Hooray! It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. Chemical Formula: (C6H10O5)n 1.4. A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. Home. Alginates also function as actives in some anti-reflux products. Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . LOT #: Available upon request. B;vLZpHU%ChUyD+[ (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4( ESE;m& %QL((((((((((((((((((((((((((((((((((((((((P3NhC Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. Have an order or account question, find answers in our Online Support articles. It is available in different grades and particle sizes. If breathing is difficult or if . <> Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. Superior Performance: Provides excellent water uptake and rapid swelling . No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . Product Name: Microcrystalline Cellulose 1.2. Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. Some substance identifiers may have been claimed confidential, or may . endobj AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. xv}O2' H~KEe9>G/,:9\i It is . 6 Are you looking for information about products and services by region? 1 0 obj << Safety Data Sheet for Cellulose microcrystalline 102331. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . Have an order or account question? Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. Avicel PC 611 (FMC Biopolymer) . Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. << Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) Are you sure you want to delete your template? Revision No. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. Report Category. However, if handling bulk powders, observance of appropriate safeguards is recommended. EMCOCEL 90 M. 130. . Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. <> SUBSTANCE IDENTIFICATION 1.1. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. This is unlikely to be a problem when Microcrystalline cellulose is consumed as part of a medical product where it is used as an excipient in the formulation. Date Approved: 05/25/2010. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. Microcrystalline Cellulose Side Effects. All rights reserved. Microcrystalline Cellulose; Cellulose; Functions. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. Watch Now. We know that our customers need to provide reliable and consistent products to their patients. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. };khd5x=fr iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? INCI. It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. Powder becomes slippery when wet. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe Watch Now. 1.3. pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b cas:9000-11-7 msds Carboxymethyl cellulose. MATERIAL SAFETY DATA SHEET. Microcrystalline cellulose (C6H10O5)n is refined wood pulp. Protect them from sunshine or rain. The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. If you are already a ChemPoint customer then sign up for access to our online ordering website. cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. 8 0 obj Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. No. No. <> Trademarks: Avicel PH-102. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. Microcrystalline Cellulose (MCC) Manufacturing Industry. GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . Well-recognized product that can do it all. Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. Microcrystalline Cellulose (MCC) MSDS 1. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. >> The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. It is also inert and biocompatible. [FMC Study Number I92-1464]. Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. endstream Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. 4 0 obj The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication. These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. In extrusion-spheronisation, it is the excipient of choice. It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. No. /Type/Page FMC Corporation. /Parent 3 0 R Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. HMo@9, U Q!R/1*;` 5 0 obj Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. <> At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. ). Request media, explore upcoming events and read our latest updates. Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological .